文章基本信息

标题：Modelling the Cost-Effectiveness of Implementing a Dietary Intervention in Renal Transplant Recipients
本地全文：下载
作者：Friso B. Coerts ; Judith J. Gout-Zwart ; Eke G. Gruppen 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：4
页码：1175
DOI：10.3390/nu13041175
出版社：MDPI Publishing
摘要：Background: The Dietary Approach to Stop Hypertension (DASH) and potassium supplementation have been shown to reduce the risk of death with a functioning graft (DWFG) and renal graft failure in renal transplant recipients (RTR). Unfortunately, a key problem for patients is the adherence to these diets. The aim of this study is to evaluate the cost-effectiveness and budget impact of higher adherence to either the DASH or potassium supplementation. Methods: A Markov model was used to simulate the life course of 1000 RTR in the Netherlands. A societal perspective with a lifetime time horizon was used. The potential effect of improvement of dietary adherence was modelled in different scenarios. The primary outcomes are the incremental cost-effectiveness ratio (ICER) and the budget impact. Results: In the base case, improved adherence to the DASH diet saved 27,934,786 and gained 1880 quality-adjusted life years (QALYs). Improved adherence to potassium supplementation saved €1,217,803 and gained 2901 QALYs. Both resulted in dominant ICERs. The budget impact over a five-year period for the entire Dutch RTR population was €8,144,693. Conclusion: Improving dietary adherence in RTR is likely to be cost-saving and highly likely to be cost-effective compared to the current standard of care in the Netherlands.
关键词：renal transplant recipients; kidney failure; dietary approaches to stop hypertension; diet; cost analysis; cost effectiveness; food technology renal transplant recipients ; kidney failure ; dietary approaches to stop hypertension ; diet ; cost analysis ; cost effectiveness ; food technology