文章基本信息

标题：Multiple Micronutrients, Including Zinc, Selenium and Iron, are Positively Associated with Anemia in New Zealand Aged Care Residents
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作者：Sue O. MacDonell ; Jody C. Miller ; Michelle J. Harper 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：4
页码：1072
DOI：10.3390/nu13041072
出版社：MDPI Publishing
摘要：Anemia is a significant comorbidity for older adults not fully attributable to iron deficiency. Low-grade inflammation and other micronutrient deficiencies also contribute. This cross-sectional study examined the relationships between nutrient and non-nutrient factors with hemoglobin and anemia in 285 residents (>65 years) of 16 New Zealand aged-care facilities. Blood samples were analyzed for hemoglobin, ferritin, sTfR, hepcidin, zinc, selenium, and interleukin-6 (IL-6), (with ferritin, sTfR, zinc and selenium adjusted for inflammation). Linear regression models examined the relationships between micronutrient biomarkers (iron, zinc, selenium, vitamin B-12 and D), age, sex, and health factors with hemoglobin. Thirty-two percent of participants exhibited anemia, although <2% had either depleted iron stores or iron deficiency. Plasma zinc and selenium deficiencies were present in 72% and 38% of participants, respectively. Plasma zinc and total body iron (TBI) were positively associated (p < 0.05) with hemoglobin, while gastric acid suppressing medications, hepcidin, and interleukin-6 were inversely associated. These relationships were maintained after the application of anemia cut-offs. These findings emphasize the importance of considering multiple micronutrient deficiencies as risk factors for anemia.
关键词：anemia; inflammation; nursing home; anti-secretory medications; proton pump inhibitors; interleukin-6; soluble transferrin receptor; total body iron anemia ; inflammation ; nursing home ; anti-secretory medications ; proton pump inhibitors ; interleukin-6 ; soluble transferrin receptor ; total body iron