摘要:The Candida antarctica lipase B immobilized on polyurethane catalyzed of esterification butanoic acid with ethyl alcohol in mechanical and ultrasonic system in a system solventfree, was studied. The maximum of ethyl butanoate esterification obtained 666.40 and 585.84 U.g -1 , whit 6 cycles de reuse in mechanical agitation (160 rpm) and mechanical ultrasound system (maximum power 1800 A, US 40 KHz, US 132 W) after 180 minutes of reaction time. The process was considered efficient with significant reduction of the reaction time, low instrumental requirements and improve the bioprocess performance. Until now, there were no studies available in the open literature in relation to the ester synthesis catalyzed by immobilized lipase in polyurethane as support in the ultrasound system. In addition, considered an environmentally correct and economically viable technology, it can be used in cosmetics, pharmaceuticals and food industry.