文章基本信息

标题：Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis
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作者：Ameer Al-Hadidi ; Jason Navarro ; Steven D. Goodman 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：3
页码：918
DOI：10.3390/nu13030918
出版社：MDPI Publishing
摘要：Necrotizing enterocolitis (NEC) is a devastating disease predominately found in premature infants that is associated with significant morbidity and mortality. Despite decades of research, medical management with broad spectrum antibiotics and bowel rest has remained relatively unchanged, with no significant improvement in patient outcomes. The etiology of NEC is multi-factorial; however, gastrointestinal dysbiosis plays a prominent role in a neonate’s vulnerability to and development of NEC. Probiotics have recently emerged as a new avenue for NEC therapy. However, current delivery methods are associated with potential limitations, including the need for at least daily administration in order to obtain any improvement in outcomes. We present a novel formulation of enterally delivered probiotics that addresses the current limitations. A single enteral dose of Lactobacillus reuteri delivered in a biofilm formulation increases probiotic survival in acidic gastric conditions, increases probiotic adherence to gastrointestinal epithelial cells, and reduces the incidence, severity, and neurocognitive sequelae of NEC in experimental models.
关键词：necrotizing enterocolitis; prematurity; Lactobacillus reuteri ; probiotics; dextranomer microspheres necrotizing enterocolitis ; prematurity ; Lactobacillus reuteri ; probiotics ; dextranomer microspheres