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标题：Combined effects of dietary zinc at 3 years of age and obesity at 7 years of age on the serum uric acid levels of Korean children
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作者：Sung Hee Lee ; Hye Ah Lee ; Eun Ae Park 等
期刊名称：Nutrition Research and Practice
印刷版ISSN：1976-1457
出版年度：2020
卷号：14
期号：4
页码：365-373
DOI：10.4162/nrp.2020.14.4.365
出版社：KoreaMed Synapse
摘要：BACKGROUND/OBJECTIVES :To assess the longitudinal associations of the antioxidant capacity of zinc and body mass index (BMI) with serum uric acid (SUA) in South Korean children. SUBJECTS/METHODS :Using follow-up data from the Ewha Birth and Growth Cohort, we included subjects who were seen at 3 and 7 years of age (n = 183; 90 boys, 93 girls). Daily zinc intake and BMI were assessed at 3 and 7 years of age. SUA measured at 7 years was used as the outcome variable. Using a general linear model, the effects of dietary zinc intake and BMI on SUA were assessed. We also assessed the combined effect of early dietary zinc intake and BMI on SUA in children. RESULTS :The dietary zinc intake at 3 years of age was negatively correlated ( ρ = -0.18, P = 0.04), whereas the BMI at 7 years of age was positively correlated ( r = 0.18, P = 0.01), with the SUA level at 7 years of age. The dietary zinc intake level at 3 years of age and the BMI level at 7 years of age were, together, significantly related to SUA in children at 7 years of age. SUA was lower in group 1 (normal-weight, high-zinc group) than in the other two groups (group 2: normal-weight, low-zinc and overweight, high-zinc group; and group 3: overweight, low-zinc group). Our results demonstrate the combined effect of zinc intake and BMI on SUA. The combined association remained significant in both the crude and adjusted models ( P < 0.01). CONCLUSIONS :SUA was related to combined BMI and dietary zinc intake, and increased zinc intake and normal body weight had a beneficial effect on reducing SUA in children. ©2020 The Korean Nutrition Society and the Korean Society of Community Nutrition.
关键词：Uric acid;antioxidants;pediatric obesity;zinc