文章基本信息

标题：Furo[3,2-c]coumarin-derived Fe 3 Selective Fluorescence Sensor: Synthesis, Fluorescence Study and Application to Water Analysis
本地全文：下载
作者：Norfatirah Muhamad Sarih ; Alexander Ciupa ; Stephen Moss 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2020
卷号：10
期号：1
页码：1-11
DOI：10.1038/s41598-020-63262-7
出版社：Springer Nature
摘要：Furocoumarin (furo[3,2-c]coumarin) derivatives have been synthesized from single step, high yielding (82–92%) chemistry involving a 4-hydroxycoumarin 4 1 cycloaddition reaction. They are characterized by FTIR, 1H-NMR, and, for the first time, a comprehensive UV-Vis and fluorescence spectroscopy study has been carried out to determine if these compounds can serve as useful sensors. Based on the fluorescence data, the most promising furocoumarin derivative (2-(cyclohexylamino)-3-phenyl-4H-furo[3,2-c]chromen-4-one, FH), exhibits strong fluorescence (ФF = 0.48) with long fluorescence lifetime (5.6 ns) and large Stokes’ shift, suggesting FH could be used as a novel fluorescent chemosensor. FH exhibits a highly selective, sensitive and instant turn-off fluorescence response to Fe3 over other metal ions which was attributed to a charge transfer mechanism. Selectivity was demonstrated against 13 other competing metal ions (Na , K , Mg2 , Ca2 , Mn2 , Fe2 , Al3 , Ni2 , Cu2 , Zn2 , Co2 , Pb2 and Ru3 ) and aqueous compatibility was demonstrated in 10% MeOH-H2O solution. The FH sensor coordinates Fe3 in a 1:2 stoichiometry with a binding constant, Ka = 5.25 × 103 M−1. This novel sensor has a limit of detection of 1.93 µM, below that of the US environmental protection agency guidelines (5.37 µM), with a linear dynamic range of ~28 (~2–30 µM) and an R2 value of 0.9975. As an exemplar application we demonstrate the potential of this sensor for the rapid measurement of Fe3 in mineral and tap water samples demonstrating the real-world application of FH as a “turn off” fluorescence sensor.