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  • 标题:The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia
  • 本地全文:下载
  • 作者:Sigit Ambar Widyawati ; Suhartono Suhartono ; Maria Mexitalia
  • 期刊名称:The International Journal of Occupational and Environmental Medicine
  • 印刷版ISSN:2008-6520
  • 电子版ISSN:2008-6814
  • 出版年度:2020
  • 卷号:11
  • 期号:1
  • 页码:15-23
  • DOI:10.15171/ijoem.2020.1809
  • 出版社:National Iranian Oil Company (NIOC) Health Organization
  • 摘要:Background: Birth weight is very important for long-term physical, mental, health, and brain development. Pesticide exposure is thought to interfere with fetal growth, among others, through disruption of the function of the insulin-like growth hormone-1 (IGF-1) hormone. Objective: To analyze the relationship between exposure to pesticides during pregnancy and low-birth weight (LBW) through the disruption of the IGF-1 hormone. Methods: In a case-control study, babies born with LBW (birth weight <2500 g) and those born later with normal birth weight (≥2500 g) at 2 hospitals in Brebes were chosen as cases and controls, respectively. Maternal pesticide exposure was measured by interview using a questionnaire. Umbilical serum IGF-I level was tested using the ELISA method. Results: There was a significant relationship between pesticide exposure during pregnancy and LBW (OR 6.8; 95% CI 2.0 to 22.9) and low umbilical serum IGF-1 levels (OR 3.6; 95% CI 1.2 to 11.1). There was a significant relationship between low umbilical serum IGF-1 levels and LBW (OR 8.9; 95% CI 2.4 to 32.1). Conclusion: There was a significant relationship between pesticide exposure during pregnancy and LBW through the umbilical serum IGF-1 reduction pathway.
  • 关键词:Fetal blood;Infant;low birth weight;Insulin like growth factor I;Organophosphates;Pesticides
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