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标题：Hematological Parameters Characteristics in Children with Obstructive Sleep Apnea with Obesity
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作者：Tian Shen ; Jing Wang ; Wen Yang 等
期刊名称：Risk Management and Healthcare Policy
印刷版ISSN：1179-1594
电子版ISSN：1179-1594
出版年度：2021
卷号：Volume 14
页码：1015-1023
DOI：10.2147/RMHP.S297341
出版社：Dove Medical Press Ltd
摘要：Objective :To investigate the possible correlation between obesity and hematological parameters in children with obstructive sleep apnea (OSA). Methods :A total of 460 children was initially included in our study, which were divided into children with OSA and children without OSA. Multiple analysis was performed for obesity by adjusting confounding factors such as age and gender in 460 children. Further, to minimize the influence of confounding factors and selective bias, propensity score matching (PSM) was performed in children with OSA. Hematological parameters such as inflammatory and coagulable parameters were compared between the normal weight children with OSA and the obese children with OSA following PSM. Results :OSA (OR = 3.061; P <0.001; 95% CI, 1.772-5.288) represented an independent risk factor for obesity. Besides, the obese children with OSA had higher levels of white blood cell (WBC) ( P <0.001), neutrophil (NEUT) ( P <0.001), neutrophil-lymphocyte ratio (NLR) ( P =0.006), fibrinogen (FIB) ( P =0.033), while had a lower level of activated partial thromboplastin time (APTT) ( P =0.048). No significant differences were observed in other hematological parameters. In linear regression, the results indicated that the levels of WBC (R 2 = 0.123, Beta = 0.289, P<0.001), NEUT (R 2 = 0.124, Beta = 0.282, P<0.001), NLR (R 2 = 0.105, Beta = 0.184, P=0.026) and FIB (R 2 = 0.086, Beta = 0.246, P=0.003) were positively correlated with BMI, while the level of APTT (R 2 = 0.057, Beta = -0.171, P=0.044) was significantly negatively correlated with BMI. Conclusion :OSA was an independent risk factor contributing to obesity. WBC, NEUT, NLR, FIB and APTT are correlated with obesity in children with OSA (aged from 2 to 14 years). These indicators could be used to estimate the status of inflammation and hypercoagulation in the obese children with OSA. © 2021 Shen et al.
关键词：hematological parameter;hypercoagulation;inflammation;obesity;obstructive sleep apnea;propensity score matching