文章基本信息

标题：Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup
本地全文：下载
作者：Makoto Fujii ; Yuko Ohno ; Makoto Yamada 等
期刊名称：Environmental Health and Preventive Medicine
印刷版ISSN：1342-078X
电子版ISSN：1347-4715
出版年度：2019
卷号：24
期号：1
页码：1-9
DOI：10.1186/s12199-019-0763-2
出版社：Springer Japan
摘要：Although fat accumulation in human organs is associated with a variety of diseases, there is little evidence about the effect of a fatty pancreas on the development of subclinical chronic pancreatitis over the clinical course. We conducted a prospective cohort study from 2008 to 2014 of patients who underwent a medical checkup consultation for fat accumulated in the pancreas. Patients included in the analysis were divided into a non-fatty pancreas group (n = 9710) and fatty pancreas group (n = 223). The primary end point was the odds ratio (OR) for chronic pancreatitis associated with fatty pancreas, which was diagnosed using ultrasonography. We used a multiple logistic regression model to estimate the OR and the corresponding 95% confidence interval (CI). Ninety-two people were diagnosed with chronic pancreatitis, including both presumptive and definitive diagnoses. Twelve people were diagnosed with chronic pancreatitis by ultrasonography among the 223 patients with fatty pancreas, and 80 patients among 9710 were diagnosed with non-fatty pancreas. The crude OR was 6.85 (95% CI 3.68, 12.75), and the multiple adjusted OR was 3.96 (95% CI 2.04, 7.66). Fat accumulation in the pancreas could be a risk factor for developing subclinical chronic pancreatitis.
关键词：Pancreas;Fat accumulation;Ectopic fat;Chronic pancreatitis;Cohort study