文章基本信息

标题：The Relation between Karyotype Findings and Gonadotropin Levels in Pediatric Turner’s syndrome Patients
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作者：Fatemeh Zarei ; Moein Mobini ; reza Jafarzadeh Esfehani 等
期刊名称：International Journal of Pediatrics
印刷版ISSN：2345-5047
电子版ISSN：2345-5055
出版年度：2021
卷号：9
期号：2
页码：13005-13011
DOI：10.22038/ijp.2020.54327.4296
出版社：Mashhad University of Medical Sciences
摘要：Background Abnormal pubertal development and fertility are among the frequent complications in Turner’s syndrome. Although elevated level of gonadotropins in Turner’s syndrome patients is well documented, the possible correlation with the karyotype findings and anthropometric features of patients is not clearly addressed. The present report aimed to evaluate the relation between the follicle-stimulating hormone (FSH) serum level and cytogenetic findings in Iranian Turner’s syndrome patients. Materials and Methods: Abnormal pubertal development and fertility are among the frequent complications in Turner’s syndrome. Although elevated level of gonadotropins in Turner’s syndrome patients is well documented, the possible correlation with the karyotype findings and anthropometric features of patients is not clearly addressed. The present report aimed to evaluate the relation between the follicle-stimulating hormone (FSH) serum level and cytogenetic findings in Iranian Turner’s syndrome patients. Results: The mean age of the Turner’s syndrome patients was 9.78 years and most of the patients were mosaic for Turner syndrome (54.3%). Although the FSH level increased, there was not any significant different between the FSH level in the initial evaluation and the second evaluation within the entire study population (P=0.605). Among those who were mosaic for Turner’s syndrome and those with 45,XO karyotype, the FSH level increased during the follow up (P=0.476, and P=0.357, respectively). Conclusion The present study demonstrated that although Turner’s syndrome patients face abnormal FSH levels, there is not any significant relation between the cytogenetic findings as well as anthropometric characteristics including height, weight and BMI with the serum FSH levels.
关键词：Follicle-Stimulating Hormone ; Karyotype ; Turner’s syndrome