文章基本信息

标题：Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice
本地全文：下载
作者：Boguen Kwon ; SooYeon Hong ; Eun-Young Kim 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：3
页码：839
DOI：10.3390/nu13030839
出版社：MDPI Publishing
摘要：Cone of Pinus densiflora (CP), or Korean red pinecone, is a cluster of Pinus densiflora fruit. CP has also been verified in several studies to have anti-oxidation, anti-fungal, anti-bacterial, and anti-melanogenic effects. However, anti-inflammatory effects have not yet been confirmed in the inflammatory responses of pinecones to allergic contact dermatitis. The purpose of this study is to prove the anti-inflammatory effect of CP on allergic contact dermatitis (ACD) in vitro and in vivo. CP inhibited the expression of TSLP, TARC, MCP-1, TNF-α, and IL-6 in TNF-α/IFN-γ-stimulated HaCaT cells and MCP-1, GM-CSF, TNF-α, IL-6, and IL-8 in PMACI (phorbol-12-myristate-13-acetate plus A23187)-stimulated HMC-1 cells. CP inhibited the phosphorylation of mitogen-activated protein kinase (MAPKs), as well as the translocation of NF-κB on TNF-α/IFN-γ stimulated in HaCaT cells. In vivo, CP decreased major symptoms of ACD, levels of IL-6 in skin lesion, thickening of the epidermis and dermis, infiltration of eosinophils and mast cells, and the infiltration of CD4 T cells and CD8 T cells. This result suggests that CP represents a potential alternative medicine to ACD for diseases such as chronic skin inflammation.
关键词：cone of pinus densiflora ; allergic contact dermatitis; HaCaT; HMC-1; MAPK; NF-κB; TARC; MCP-1 cone of pinus densiflora ; allergic contact dermatitis ; HaCaT ; HMC-1 ; MAPK ; NF-κB ; TARC ; MCP-1