文章基本信息

标题：Retinal Neurodegeneration: Correlation between Nutraceutical Treatment and Animal Model
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作者：Ilaria Piano ; Mattia Di Paolo ; Francesca Corsi 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：3
页码：770
DOI：10.3390/nu13030770
出版社：MDPI Publishing
摘要：Retinal diseases can be induced by a variety of factors, including gene mutations, environmental stresses and dysmetabolic processes. The result is a progressive deterioration of visual function, which sometimes leads to blindness. Many treatments are under investigation, though results are still mostly unsatisfactory and restricted to specific pathologies, particularly in the case of gene therapy. The majority of treatments have been tested in animal models, but very few have progressed to human clinical trials. A relevant approach is to study the relation between the type of treatments and the degenerative characteristics of the animal model to better understand the effectiveness of each therapy. Here we compare the results obtained from different animal models treated with natural compounds (saffron and naringenin) to anticipate the potentiality of a single treatment in different pathologies.
关键词：retinal degeneration; oxidative stress; nutraceutical compounds; preventative therapy retinal degeneration ; oxidative stress ; nutraceutical compounds ; preventative therapy