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标题：Efficacy of Polyphenols in the Management of Dyslipidemia: A Focus on Clinical Studies
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作者：Francis Feldman ; Mireille Koudoufio ; Yves Desjardins 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：2
页码：672
DOI：10.3390/nu13020672
出版社：MDPI Publishing
摘要：Polyphenols (PLPs), phytochemicals found in a wide range of plant-based foods, have gained extensive attention in view of their antioxidant, anti-inflammatory, immunomodulatory and several additional beneficial activities. The health-promoting effects noted in animal models of various non-communicable diseases explain the growing interest in these molecules. In particular, in vitro and animal studies reported an attenuation of lipid disorders in response to PLPs. However, despite promising preclinical investigations, the effectiveness of PLPs in human dyslipidemia (DLP) is less clear and necessitates revision of available literature. Therefore, the present review analyzes the role of PLPs in managing clinical DLP, notably by dissecting their potential in ameliorating lipid/lipoprotein metabolism and alleviating hyperlipidemia, both postprandially and in long-term interventions. To this end, PubMed was used for article search. The search terms included polyphenols, lipids, triglycerides, cholesterol, LDL-cholesterol and /or HDL-cholesterol. The critical examination of the trials published to date illustrates certain benefits on blood lipids along with co-morbidities in participant’s health status. However, inconsistent results document significant research gaps, potentially owing to study heterogeneity and lack of rigor in establishing PLP bioavailability during supplementation. This underlines the need for further efforts in order to elucidate and support a potential role of PLPs in fighting DLP.
关键词：polyphenols; dyslipidemia; lipoproteins; nutrition; oxidative stress; inflammation; microbiota; metabolic syndrome; type 2 diabetes polyphenols ; dyslipidemia ; lipoproteins ; nutrition ; oxidative stress ; inflammation ; microbiota ; metabolic syndrome ; type 2 diabetes