文章基本信息

标题：Effects of High Salt Intake on Detrusor Muscle Contraction in Dahl Salt-Sensitive Rats
本地全文：下载
作者：Ryoya Kawata ; Yuji Hotta ; Kotomi Maeda 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：2
页码：539
DOI：10.3390/nu13020539
出版社：MDPI Publishing
摘要：High salt intake has been reported as a risk factor for urinary storage symptoms. However, the association between high salt intake and detrusor muscle contraction is not clear. Therefore, we investigated the effects of high salt intake on the components of detrusor muscle contraction in rats. Six-week-old male Dahl salt-resistant (DR; n = 5) and Dahl salt-sensitive (DS; n = 5) rats were fed a high salt (8% NaCl) diet for one week. The contractile responses of the detrusor muscle to the cumulative administration of carbachol and electrical field stimulation (EFS) with and without suramin and atropine were evaluated via isometric tension study. The concentration–response curves of carbachol were shifted more to the left in the DS group than those in the DR group. Contractile responses to EFS were more enhanced in the DS group than those in the DR group (p < 0.05). Cholinergic component-induced responses were more enhanced in the DS group than those in the DR group (p < 0.05). High salt intake might cause urinary storage symptoms via abnormalities in detrusor muscle contraction and the enhancement of cholinergic signals. Excessive salt intake should be avoided to preserve bladder function.
关键词：lower urinary tract symptoms; salt-sensitivity; detrusor muscle; rats lower urinary tract symptoms ; salt-sensitivity ; detrusor muscle ; rats