文章基本信息

标题：The Gut‒Breast Axis: Programming Health for Life
本地全文：下载
作者：Juan M. Rodríguez ; Leónides Fernández ; Valerie Verhasselt 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：2
页码：606
DOI：10.3390/nu13020606
出版社：MDPI Publishing
摘要：The gut is a pivotal organ in health and disease. The events that take place in the gut during early life contribute to the programming, shaping and tuning of distant organs, having lifelong consequences. In this context, the maternal gut plays a quintessence in programming the mammary gland to face the nutritional, microbiological, immunological, and neuroendocrine requirements of the growing infant. Subsequently, human colostrum and milk provides the infant with an impressive array of nutrients and bioactive components, including microbes, immune cells, and stem cells. Therefore, the axis linking the maternal gut, the breast, and the infant gut seems crucial for a correct infant growth and development. The aim of this article is not to perform a systematic review of the human milk components but to provide an insight of their extremely complex interactions, which render human milk a unique functional food and explain why this biological fluid still truly remains as a scientific enigma.
关键词：human milk; gut-breast axis; entero-mammary pathway; immunomodulation; tolerance; gut colonization human milk ; gut-breast axis ; entero-mammary pathway ; immunomodulation ; tolerance ; gut colonization