文章基本信息

标题：Hydroetanolic extract activity of Raphanus Sativus leaves in submandibular glands of rats with diabetes mellitus
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作者：Aluísio Eustáquio de Freitas Miranda Filho ; Amanda Basílio Silva ; Érica Apolicauto 等
期刊名称：Research, Society and Development
电子版ISSN：2525-3409
出版年度：2021
卷号：10
期号：2
页码：1-9
DOI：10.33448/rsd-v10i2.12447
出版社：Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
摘要：Diabetes mellitus (DM) is a disease identified by the high level of glucose in the blood that results from a defect in insulin secretion. Individuals with uncontrolled diabetes have important changes in the oral cavity, such as periodontitis and hyposalivation, making them more predisposed to cavities, dry mouth, in addition to affecting immunity and increasing susceptibility to infections. In this study, the activity of the hydroethanolic extract of Raphanus sativus (radish) was evaluated in reducing glycemia and oxidative stress in male wistar rats induced by diabetes using Alloxane (120 mg / kg) and treated over a 90-day period with Raphanus Sativus extract daily by gavage at a concentration of 300 mg / kg / day. The tested extract showed positive results, acting in the reduction of glycemia and oxidative stress, reducing lipoperoxidation (MDA) and protein oxidation in the submandibular glands of rats with diabetes. The hydroethanolic extract of Raphanus sativus has normoglycemic properties and the antioxidant effects were able to reverse the cellular damage caused by oxidative stress. The results of this work show that the extract of Raphanus sativus can become a therapeutic option for the control of glycemia and for the treatment of DM damage involving the oral cavity.