文章基本信息

标题：Gut Hormones in Health and Obesity: The Upcoming Role of Short Chain Fatty Acids
本地全文：下载
作者：Habeeb Alhabeeb ; Ali AlFaiz ; Emad Kutbi 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：2
页码：481
DOI：10.3390/nu13020481
出版社：MDPI Publishing
摘要：We are currently facing an obesity pandemic, with worldwide obesity rates having tripled since 1975. Obesity is one of the main risk factors for the development of non-communicable diseases, which are now the leading cause of death worldwide. This calls for urgent action towards understanding the underlying mechanisms behind the development of obesity as well as developing more effective treatments and interventions. Appetite is carefully regulated in humans via the interaction between the central nervous system and peripheral hormones. This involves a delicate balance in external stimuli, circulating satiating and appetite stimulating hormones, and correct functioning of neuronal signals. Any changes in this equilibrium can lead to an imbalance in energy intake versus expenditure, which often leads to overeating, and potentially weight gain resulting in overweight or obesity. Several lines of research have shown imbalances in gut hormones are found in those who are overweight or obese, which may be contributing to their condition. Therefore, this review examines the evidence for targeting gut hormones in the treatment of obesity by discussing how their dysregulation influences food intake, the potential possibility of altering the circulating levels of these hormones for treating obesity, as well as the role of short chain fatty acids and protein as novel treatments.
关键词：obesity; gut hormones; short chain fatty acids; diabetes; overweight; food intake; appetite; glucagon-like peptide-1; peptide tyrosine tyrosine; neuropeptide Y obesity ; gut hormones ; short chain fatty acids ; diabetes ; overweight ; food intake ; appetite ; glucagon-like peptide-1 ; peptide tyrosine tyrosine ; neuropeptide Y