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标题：A Rare Case of Suicide by Ingestion of Phorate: A Case Report and a Review of the Literature
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作者：Angelo Montana ; Venerando Rapisarda ; Massimiliano Esposito 等
期刊名称：Healthcare
电子版ISSN：2227-9032
出版年度：2021
卷号：9
期号：2
页码：131
DOI：10.3390/healthcare9020131
出版社：MDPI Publishing
摘要：Phorate is a systemic organophosphorus pesticide (OP) that acts by inhibiting cholinesterases. Recent studies have reported that long-term low/moderate exposure to OP could be correlated with impaired cardiovascular and pulmonary function and other neurological effects. A 70-year-old farmer died after an intention ingestion of a granular powder mixed with water. He was employed on a farm for over 50 years producing fruit and vegetables, and for about 20 years, he had also applied pesticides. In the last 15 years, he used phorate predominantly. The Phorate concentration detected in gastric contents was 3.29 µg/mL. Chronic exposure to phorate is experimentally studied by histopathological changes observed in the kidney. In the light of current literature, our case confirms that there is an association between renal damage and chronic exposure to phorate in a subject exposed for years to the pesticide. Autopsies and toxicological analyses play a key role in the reconstruction of the dynamics, including the cause of the death.
关键词：phorate; acute toxicity; chronic toxicity; histopathological kidney; toxicological examination phorate ; acute toxicity ; chronic toxicity ; histopathological kidney ; toxicological examination