文章基本信息

标题：Synthesis, Characterization and In-Silico Analysis of New 2-Pyrazolines
本地全文：下载
作者：T. Saroja ; R. M. Ezhilarasi ; V. Selvamani 等
期刊名称：Journal of Scientific Research
印刷版ISSN：2070-0237
电子版ISSN：2070-0245
出版年度：2021
卷号：13
期号：1
页码：183-194
DOI：10.3329/jsr.v13i1.46995
出版社：Rajshahi University
其他摘要：Heterocyclic compounds such as pyrazolines, pyrimidines, oxazole and isoxazole exhibit different pharmacological activities. The current study involves synthesis of new 2-pyrazolines. The synthesis involves the cyclocondensation reaction of substituted chalcones with (4-fluorophenylthio)acetic acid hydrazide (FTAH) under reflux. The chalcones (C1-C7 / 1a-1g) were synthesized from the reaction of substituted acetophenone with substituted benzaldehyde and FTAH was prepared from 4-fluro thiophenol. New 2-pyrazolines were obtained in good yields (60-70 %). All the compounds were characterized by FT-IR, 1H, 13C NMR and mass spectra. PASS analysis was carried out for the 2-pyrazolines synthesized (P1-P7 / 3a-3g).
关键词：2-pyrazolines; PASS; Chalcones; Hydrazide