文章基本信息

标题：Scavenging Effects of Flavonoids on Paraquat Induced Pulmonary Toxicity
其他标题：Paraquat 유도 폐독성에 대한 Flavonoid류의 독성경감 효과
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作者：Choi Byung Ki ; Nai Kyu Cho
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1995
卷号：10
期号：2
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：To investigate and evaluate the scavenging and antioxidative effects of various flavonoids on paraquat induced pulmonary toxicity,in vivo and vitro tests of eight flavonoids(catechint epicatechin,flavone,chrysin. apigenin,quercetin,morin and biochanin A) were carried out. In vitro test,inhibitory and antioxidative effects of lipoxygenase dependent lipidpero-xidation,NADPH dependent cytochrome p-450 reductase to liver and lung microsome and superoxide anion production in rat peritoneal exudated macrophage were studied. In vivo test,biochemical parameters and cell population in bronchoalveolar lavage fluid(BALF) in mouse and rats after administration of paraquat and flavonoids were tested. The results are summerized as follows; 1. All flavonoids tested inhibited on NADPH dependent cytochrome p-450 reductase in liver and lung microsome. 2. All flavonoids tested showed the inhibitory effects on the superoxide anion production in rat peritoneal exudated macropharge. 3. Lactate dehydrogenase,acid phosphatase and total protein in BALF of mouse which increased by the administration of paraquat,decreased significantly by catechin,chrysin,morin and biochanin A. 4. Numbers of alveolar macropharge and PMN in BALF of rats which increased by the administration of paraquat decreased by all the tested flavonoids. Therefore,all flavonoids tested showed the useful compounds for scavenger and antioxidant on paraquat induced pulmonary toxicity.