文章基本信息

标题：Effect of famotidine on propranolol elimination in the isolated perfused rat liver
其他标题：Famotidine이 propranolol 대사에 미치는 작용
本地全文：下载
作者：Tai Soon Cho ; Doo Soon Park ; Mee Jung Park 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1994
卷号：9
期号：1
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：The H2-antagonist,cimetidine,has been shown to retard the hepatic elimination of low and high clearance drugs,and this has been attributed to inhibition of microsomal cytochrome P-450. This study was done to determine the effects of low (50//g) and high (lmg) dose of famotidine,another histamine H2-receptor antagonist,on hepatic elimination of propranolol compared with cimetidine in the isolated perfused rat liver. Both low and high dose of cimetidine not only inhibited the elimination of propranolol but also increased the area under the perfusate propranolol concentration time curve (AUC). In contrast,low and high dose of famotidine did not affect hepatic elimination of propranolol. Our findings suggest that famotidine has not a propensity for hepatic microsomal inhibition.