文章基本信息

标题：Studies on the Hemolytic Mechanism of Antitumor Platinum Complex
其他标题：항암성 백금화합물의 용혈독성기전에 관한 연구
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作者：Byung Ki Choi ; Young Sook Park ; Se Young Choung 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1993
卷号：8
期号：2
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：This study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (II) complex (RC-1),which was synthesized recently. Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation,methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialde-hyde levels in RC-1 treated erythrocytes. So,the mechanism of hemolysis was considered to be the generation of free radicals,methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.