文章基本信息

标题：The Toxic Effect of Fthalide in Rats
其他标题：Rats에 있어서 Fthalide의 독성에 관한 연구
本地全文：下载
作者：Sa Uk Hong ; Young Chan Kim ; Jung Jin Kim 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1993
卷号：8
期号：1
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：This study was done to determine the toxic effect of fthalide in rats which have oral administration at levels of 100 mg/kg/day for twelve days. It was examined the hematogram and serological parameters,and also the content of cytochrome P-450,the activity of NADPH-cytochrome c reductase,glucose-6-phosphatase,cholinesterase and carboxylesterase in liver. Any significant alteration of hematogram was not found but the value of AST,LDH and content of glucose in serum were statistically increased. The content of cytochrome P-450,the activty of NADPH-cytochrome c reductase were increased but glucose-6-phosphatase were slightly decreased compare with that of control group. The activity of cholinesterase was decreased slightly and on the contrary the activity of carboxylesterase was found to be the tendeny of increase in both of liver and serum.