文章基本信息

标题：Effect of Synethrin on the T oxicity of Dichlorvos in Rat
其他标题：Rat의 Dichlorvos의 독성에 미치는 Synethrin의 영향
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作者：Sa Uk Hong ; Chan Bo Park
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1992
卷号：7
期号：2
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Effect of Synethrin on the Toxicity of Dichlorvos in Rats. Hematological,biological and enzymatic effects were investigated in rats treated with DDVP and synethrin. Mutagenicity was also examined. In serological analysis,LDH and ALP were more significantly increased in rats treated with the mixture of DDVP (10 mg/kg) and synethrin (250 mg/kg) than with either DDVP or synethrin. DDVP alone slightly increased cytochrome P- 450 in the liver while synethrin or the mixture decreased it. Lipid peroxidation was significantly increased in the liver when rats were treated with both DDVP and the mixture. Cholinesterase activity was significantly decreased in the liver and serum when treated with DDVP as well as with the mixture. In mutagenicity test,DDVP was shown to be weakly positive to TA 97a,TA 100 and TA 102,but negative to TA 1537. Synethrin showed negative in all strains tested. These results suggest that the mixture of DDVP and synethrin increased the tox- icities but not the mutagenicity.