文章基本信息

标题：Toxic Effect of S-bioallethrin in Rats
其他标题：Rat에 있어서 S-bioallethrin 독성에 관한 연구
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作者：Sa Uk Hong ; Hyung Sik Kim ; Kyu Hyuck Chung 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1992
卷号：7
期号：1
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：The object of this study is to investigate the toxicity of S biol (d-allethron-d-trans -chrysanthemate) and the mode of action between other synthetic pyrethroid insecti- cides and S-biol in rats. Rats were treated daily with S - biol (25 mg/kg,50 mg/kg,100 mg/kg) by oral administration for 5 weeks. The experimental results were summerized as follows: Biochemical parameters such as LDH and Glucose in serum were much more in. creased in control groups. No significant hematological change excepts for MCHC in rats treated with S-biol 100 mg/kg were observed in all groups compared to control groups. In animals treated with S-biol for 4~5 weeks,the levels of cytochrome P-450 in the liver were significantly increased. In renal microsomal fractions,however,no signifi- cant changes of cytochrome P-450 contents were observed. The activitis of ATPase in groups treated with S -biol (50 mg/kg,100 mg/kg) were decreased compared to those in other groups. TBA values and activities of glucose- 6- phosphatase in the liver were increased a little in the groups treated with S-biol (100 mg/kg) for 5 weeks. The activities of cholinesterase in hepatic and serum were not significantly changed in all groups but slightly decreased in animals treated with high dose of S-biol (100 mg/ kg). The activities of carboxylesterase in serum and in the liver were slightly increased but not significantly changed.