文章基本信息

标题：Studies on the Bis (amino-alkyl-oxo) Oxalate Derivatives As a Antidote of Lead poisoning
其他标题：Bis ( β - amino - alkyl - oxo ) oxalate 유도체의 납 중독 해독에 관한 연구
本地全文：下载
作者：Seun Ah Choi ; Mi Rhe You ; Y oung Soo Rho 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1989
卷号：4
期号：2
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：The effects of bis (B amino-ethyl-oxo) oxalate and bis (a amino-methyl-oxo) oxalate on the toxicity of lead acetate in rast were examined. Rats were given intraperitoneally at the dose of lead acetate 45 mg/kg. The exposure of lead acetate showed the 70% decrease of ALAD (8-amino levulinic acid dehydratase) activity in red blood cell. In vivo 122 mg/kg administration of bis (8-amino-ethyl-oxo) oxalate and bis (a- amino-methy1-oxo) oxalate showed the 50% increase of ALAD activity,whereas 149 mg/ kg administeration of Ca-EDTA had no effect. In vitro,the same results were obtained. Both compounds had hemolytic activity at concentrations higher than that required for showing the 50% ALAD activity increase in vivo.