文章基本信息

标题：Effect of Ethanol on the Immunotoxicity of Doxycycline in Mice
其他标题：마우스에 있어서 Doxycycline의 면역독성에 미치는 Ethanol의 영향
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作者：Young Keun Ahn ; Jung Hoon Kim ; Zi Gun Chung 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1989
卷号：4
期号：1
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Experiments were performed on mice to investigate the influences of doxycycine and ethanol on the immune responses. Doxycycline was injected intraperitoneally and ethanol was administered in the drinking water. Mice were sensitized and challenged with sheep red blood cells. Immune responses were evaluated by humoral immunity, cellular immunity,peripheral circulating white blood cell and phagocyte activity. Pathotoxicological influences were measured by serum protein and albumin. The weight of spleen,thymus and liver were measured. Doxycline and ethanol combined administration decreased the weight of thymus and spleen. Humoral and cellular immune response were reduced by doxycycline administration. Especially ethanol combined administration significantly reduced humoral and cellu- lar immune response. Phagocyte activity was increased by ethanol combined administration and peripheral circulating white blood cell was significantly increased by ethanol adminstration. Ethanol combined administration decreased serum A/G ratio.