文章基本信息

标题：Effect of Ginseng petroleum Ether Fraction on the Immunotoxicity of Cadmium in Mice (I)
其他标题：마우스에 있어서 카드뮴의 면역독성에 미치는 인삼석유 Ether분획의 영향 ( I )
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作者：Young Keun Ahn ; Jung Hook Kim ; Sang Keun Lee 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：1988
卷号：3
期号：1
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Experiment was performed to investigate the immunotoxicity of cadmium adminis- tered orally and the effect of ginseng petroleum ether fraction on it. Mice were given 3,30,or 300 ppm cadmium as cadmium chloride orally in the drinking water and injection of ginseng petroleum ether fraction intraperitoneally for 4 weeks. Mice were sensitized and challenged with sheep red blood cells (S- RBC). Humoral immune response was evaluated by antibody production and Arthus reaction. Body weight gain,spleen weight,thymus weight,and liver weight were also measured. In the present study,cadmium generally suppressed the humoral immunity. There was decrease in the rate of body weight gain and liver weight to body weight by cadmium- administration. Ginseng petroleum ether fraction showed restoring effect,to some extent,on the decrease in PFC and in the rate of liver weight to body weight by cadmium- administration. But it more suppressed Arthus reaction.