文章基本信息

标题：Evaluation of Hepatic Antioxidant Defense Systems in Rats Treated with Tetrabromobisphenol-A
其他标题：Tetrabromobisphenol-A가 처리된 랫드의 간에서 항산화활성 평가
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作者：Sang yoon Lee ; Sang Kyum Kim ; Kang Uk Yun 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2009
卷号：24
期号：4
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Hepatic antioxidant defense systems were examined in rats treated with tetrabromobisphenol-A (TBBPA),a brominated flame retardant,at the doses of 0,250,500 and 1,000 mg/kg for four weeks. Hepatic ratio of glutathione disulfide to glutathione (GSH) and levels of malondialdehyde,oxidative stress markers were not changed in rats treated with TBBPA. Hepatic expression of antioxidant enzymes including GSH peroxdiase-1 (GPX-1)/ GSH reductase (GR),alpha-,mu- and pi-class glutathione-S-transferase (GST) and gamma-glutamylcysteine ligase catalytic subunit was determined using immunoblot analysis. Alpha-class GSTs,GPX-1 and GR levels were significantly decreased in rats treated with TBBPA at the dose of 500 or 1,000 mg/kg. These results show that TBBPA results in down-regulation of hepatic expression of antioxidant enzymes related with GSH,suggesting the liver in TBBPA-treated rats may be more sensitive to oxidants.
关键词：tetrabromobisphenol-A;antioxidant defense system;oxidative stress;liver