文章基本信息

标题：Effects on Physiological Activities Caused by Oxygen Deficiency and Exposure to Noxious Gases in SD Rats
其他标题：Rat를 이용 산소 및 유해가스 노출에 따른 운동성 변화와 치사농도 연구
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作者：Hyeon-Y eong Kim ; Sung-Bae Lee ; Jeong-Hee Han 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2009
卷号：24
期号：3
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：As an efort to prevent serious acidents involving oxygen deficiency and suffocation in confined spaces and to identify the causes of such accidents,the present study investigated relevant accidents and systems in Korea and other countries. This study also conducted a number of experiments at lethal concentration levels of oxygen deficiency using SD rats and observed the changes of experimental animals with humidity. organic gas (toluenc), hydrogen sulfide. carbon monoxide and so on al the oxygen deficient environment. The results of the study are as follows. 1,The results from the experiment conducted using SD rats at lethal concentration levels of oxygen showed that there were no casualties at the 7% oxygen concentration level,but the morality increase to 20% at 6% oxygen,it was jumped to 90% at 5% oxygen,and it was also dramatically reached 100% at 4% oxygen concentration. Therefore,5.5% was calculated as the LCso (ral,4hr) from these dose-response experiments with oxygen deficiency. 2. When we changed the level of toluene,HS. CO. humidity,and so on,in an oxygen deficient environment,it was observed that the small concentrations of HS and CO make the highest effect on animals. In case of 350 ppm HsS,it resuled in 30% mortaliy,and the 100% morality was shown in L,200ppm CO concentration. The mortality increased as an oxygen deficient condition. However in the case of toluene up 1o 1,000 ppm,it were not afcted with oxygen deficiency. and it did not indicate any significant dfferences in mortality as 20%,90% humiditics.
关键词：lethal concentration of oxygen;oxygen deficiency;LCs