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标题：Tissue Distribution of SiO2 Nanoparticles in Mice after Oral Administration or Skin Treatment
其他标题：마우스 경구 및 경피투여에 의한 Si02 나노입자의 체내분포
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作者：Eun-Jeung Park ; K wangsik Park
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2008
卷号：23
期号：2
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Tissue distribution of SiO2 nanopaprticles was investigated in mice after oral administration or skin treatment. ICR Male mice were treated with siO2 nanoparticles 2.5 g/kg/day for five consecutive days and sacriflced at 24 hours after the last administration. As results,the orally administered SIO2 nanoparticels were distrbuted in the testis and kidney but not in lung at 24 hours after the last treatment. In case of skin treatment, SiO2 nanoparicles were disunbuted to lung as well as testis,brain,kidney and liver,The results suggested that SiO2 nanoparicles(12 nm) are easily absorbed through entero- gasric system or skin.
关键词：SiO: nanoparticles;tsse distribution;brain. testis. kidney. liver