文章基本信息

标题：The Distribution of TaqI RFLP in the Vitamin D Receptor Gene in Korean Vegetarian Men and its Association with Calcaneal Bone Mineral Density
其他标题：한국인 채식 남성에서 비타민 D 수용체 유전자의 Taq I 다형성의 분포 및 종골의 골밀도와의 관련성
本地全文：下载
作者：Byung Yong Kang ; So Yeon Kim ; Sang Jin Lee 等
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2006
卷号：21
期号：1
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Numerous studies reported the significant association between genetic polymorphisms in the vitamin D receptor (VDR) gene and various bone phenotypes such as bone mineral density (BMD) and bone quality,although conflicting results were produced. The objective of this study was to investigate the association between a TaqI RFLP in the VDR gene and calcaneal BMD in Korean vegetarian men,and its interaction with nutrition status as an environmental factor. BUA (broadband ultrasound attenuation),SOS (sound of speed) and stiffness index of the calcaneus were measured using an ultrasound bone densitometer in 266 Korean men (age: mean±SD;50.9±12.0 year),and a TaqI RFLP in the VDR gene analysed by PCR-RFLP method. In total subjects,the distribution of TT,Tt and tt genotypes occurred with frequencies of 90.8%,8.8% and 0.4%,respectively. There were no significant associations between this polymorphism and osteopenia-osteoporosis or several bone phenotypes in our subjects irrespectively of nutrition status (P¤0.05). Therefore,our results suggest that a TaqI RFLP in the vitamin D receptor gene does not contribute to the susceptibility to the calcaneal BMD in Korean men.
关键词：calcaneus;vitamin D receptor and vegetarian