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标题：Effects of Subacute Oral Administration of Mancozeb on the Immunopathological Parameters and Splenocytes Proliferation in Mice
其他标题：Mancozeb의 아급성 노출이 마우스의 면역병리학적 인자 및 비장세포 증식능에 미치는 영향
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作者：Myoung- Yun Pyo ; Ae-Hee Cheong
期刊名称：Environmental Health and Toxicology
电子版ISSN：2233-6567
出版年度：2004
卷号：19
期号：4
语种：English
出版社：Korean Society of Environmental Health and Toxicology
摘要：Mancozeb,d polymene complex of zime and manganee salls of ethylene busthuocarbamate (EBDC),' used wdely In agrncultue a8 fungicides,Insectnendes,and herbicides Mancozeb can be occupationally and enironmentally exposed to human and has been teported to Induce cstrogenc activnty,theremn It 18 consndeted as an endocume dsropter Afher female ICR mce were treated Mancozeb oually at the doves of 250,1,000 and 1,500 mg/k/day for consecuve 30 day,we invesngated the efcts of Mancozeb on the 1mmunopatbological parameters (body-,thymus-,spleen-,liver- and kidny- weight,splenc ellularity,hematologcal puuameteus) and mltogen (Con A,LPS)- Induced splenocyte polferation (SP) LIver- and krdney - weght wete Incieased,but body- and thymus- weight,number of splenocyles and WBC were decucased,when compared wnth control group When splenoeytes Isolated from the muce exposed to Mancozeb for 30 days were culured Imn presence of mutogens,the SP agaumst Com A Was signficantly and dose -dependently decueased and the SP aganst LPS was also shghtly decreascd Our present results undicatc that bubacute cxposue of Mancozeb to mice mught show mmumotoxic ctfect.
关键词：Mancozeb;suboacute exposure. Immunopathology;splenocyte proliferaton