文章基本信息

标题：Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications
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作者：Ana Checa-Ros ; Antonio Jeréz-Calero ; Antonio Molina-Carballo 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：1
页码：249
DOI：10.3390/nu13010249
出版社：MDPI Publishing
摘要：Studies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (CNS), or so-called the microbiome–gut–brain axis (MGBA), is involved in diverse neuropsychiatric diseases in children and adults. In pediatric age, most studies have focused on patients with autism. However, evidence of the role played by the MGBA in attention deficit/hyperactivity disorder (ADHD), the most common neurodevelopmental disorder in childhood, is still scanty and heterogeneous. This review aims to provide the current evidence on the functioning of the MGBA in pediatric patients with ADHD and the specific role of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in this interaction, as well as the potential of the GM as a therapeutic target for ADHD. We will explore: (1) the diverse communication pathways between the GM and the CNS; (2) changes in the GM composition in children and adolescents with ADHD and association with ADHD pathophysiology; (3) influence of the GM on the ω-3 PUFA imbalance characteristically found in ADHD; (4) interaction between the GM and circadian rhythm regulation, as sleep disorders are frequently comorbid with ADHD; (5) finally, we will evaluate the most recent studies on the use of probiotics in pediatric patients with ADHD.
关键词：gastrointestinal microbiome; ADHD; circadian rhythm; fatty acids; omega-3; probiotics gastrointestinal microbiome ; ADHD ; circadian rhythm ; fatty acids ; omega-3 ; probiotics