文章基本信息

标题：Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota
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作者：Umair Shabbir ; Momna Rubab ; Eric Banan-Mwine Daliri 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：1
页码：206
DOI：10.3390/nu13010206
出版社：MDPI Publishing
摘要：Polyphenols (PPs) are the naturally occurring bioactive components in fruits and vegetables, and they are the most abundant antioxidant in the human diet. Studies are suggesting that ingestion of PPs might be helpful to ameliorate metabolic syndromes that may contribute in the prevention of several chronic disorders like diabetes, obesity, hypertension, and colon cancer. PPs have structural diversity which impacts their bioavailability as they accumulate in the large intestine and are extensively metabolized through gut microbiota (GM). Intestinal microbiota transforms PPs into their metabolites to make them bioactive. Interestingly, not only GM act on PPs to metabolize them but PPs also modulate the composition of GM. Thus, change in GM from pathogenic to beneficial ones may be helpful to ameliorate gut health and associated diseases. However, to overcome the low bioavailability of PPs, various approaches have been developed to improve their solubility and transportation through the gut. In this review, we present evidence supporting the structural changes that occur after metabolic reactions in PPs (curcumin, quercetin, and catechins) and their effect on GM composition that leads to improving overall gut health and helping to ameliorate metabolic disorders.
关键词：plant polyphenols; metabolic syndrome; biotransformation; bioavailability; gut health plant polyphenols ; metabolic syndrome ; biotransformation ; bioavailability ; gut health