文章基本信息

标题：Qu Feng Xuan Bi Formula Alleviates Airway Inflammation and Guides Clinical Treatment by Improving Bronchial Immune Balance in the Asthma Model
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作者：Po Hu ; Suofang Shi ; Li Liu 等
期刊名称：Scientific Programming
印刷版ISSN：1058-9244
出版年度：2021
卷号：2021
页码：1-10
DOI：10.1155/2021/6648834
出版社：Hindawi Publishing Corporation
摘要：Network pharmacology analysis has shown that Qu Feng Xuan Bi Formula (QFXBF) is a traditional Chinese herbal medicine used to treat bronchial asthma, with demonstrated remarkable effects; however, its effects on airway inflammation and bronchial asthma alleviation remain unclear. This study aimed to explore the underlying mechanism of QFXBF by assessing toll-like receptor-9 (TLR-9) and the downstream MAPK signaling pathway as well as the immune modulation of the Th1/Th2 balance. The results showed that the aqueous extract of QFXBF increased TLR-9 expression, regulated the downstream genes AP-1, JNK, and ERK1/2, and reduced serum IL-5 levels in the high-dose QFXBF group; meanwhile, following QFXBF treatment, IFN-γ and TNF-α levels were increased, indicating that the Th1/Th2 immune balance was reversed as predicted. These findings provide a mechanism underlying QFXBF’s effects, which significantly improves the treatment and management of patients with bronchial asthma and profoundly impacts medical information processing.