文章基本信息

标题：Cómo integrar la radioterapia estereotáxica fraccionada y el hipofraccionamiento en el manejo del cáncer de pulmón localmente avanzado en la era de la inmunoterapia
其他标题：How to integrate stereotactic body radiation therapy and hypofractionation in the management of stage III lung cancer in the age of immunotherapy
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作者：Rico, M ; Flamarique Andueza, S ; Martín Martínez, A 等
期刊名称：Anales del Sistema Sanitario de Navarra
印刷版ISSN：1137-6627
出版年度：2020
卷号：43
期号：2
页码：225-234
DOI：10.23938/assn.0855
出版社：Gobierno de Navarra. Departamento de Salud
摘要：The constant advances in the field of lung cancer immunotherapy have recently reached the treatment of locally advanced disease with the approval of durvalumab after concurrent chemoradiation. However, radiation therapy continues to be key for controlling the disease at this stage. Over the years, different strategies have been employed to try to optimize outcomes using radiotherapy, with cardiac and pulmonary toxicity as the main limitation on its success. The interest in the use of hypofractionation and stereotactic body radiation therapy for stage III non-small cell lung cancer has increased as knowledge regarding these kinds of treatments has been enhanced. Hypofractionation is a relatively frequent treatment, although the level of evidence that supports it is limited. For its part, stereotactic body radiation therapy has been particularly studied as a boost after chemoradiation, with encouraging results. In both cases, study of how to integrate these tools with chemotherapy and particularly with immunotherapy is essential, as they may have an immunomodulatory role.
关键词：Cáncer de pulmón;Hipofraccionamiento;SBRT;Inmunoterapia
其他关键词：Lung cancer;Hypofractionation;SBRT;Immunotherapy