文章基本信息

标题：Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression
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作者：Hollis Wright ; Carlos F. Aylwin ; Carlos A. Toro 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2021
卷号：11
期号：1
页码：1996
DOI：10.1038/s41598-021-81689-4
出版社：Springer Nature
摘要：Abstract Female puberty is subject to Polycomb Group (PcG)-dependent transcriptional repression. Kiss1 , a puberty-activating gene, is a key target of this silencing mechanism. Using a gain-of-function approach and a systems biology strategy we now show that EED, an essential PcG component, acts in the arcuate nucleus of the hypothalamus to alter the functional organization of a gene network involved in the stimulatory control of puberty. A central node of this network is Kdm6b , which encodes an enzyme that erases the PcG-dependent histone modification H3K27me3. Kiss1 is a first neighbor in the network; genes encoding glutamatergic receptors and potassium channels are second neighbors. By repressing Kdm6b expression, EED increases H3K27me3 abundance at these gene promoters, reducing gene expression throughout a gene network controlling puberty activation. These results indicate that Kdm6b repression is a basic mechanism used by PcG to modulate the biological output of puberty-activating gene networks.