文章基本信息

标题：Influence of acotiamide on 13C-urea breath test for Helicobacter pylori diagnosis
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作者：Kazuhiro Mizukami ; Makoto Katsuta ; Kazuhisa Okamoto 等
期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2020
卷号：67
期号：3
页码：332-337
DOI：10.3164/jcbn.20-17
出版社：The Society for Free Radical Research Japan
摘要：The Helicobacter pylori infection and functional dyspepsia are often coexisted. The effect of acotiamide, a drug for functional dyspepsia, on the result of Helicobacter pylori diagnosis has yet to be studied. We evaluated the influence of acotiamide on the results of Helicobacter pylori diagnosis in the 13 C-urea breath test. Twenty patients with Helicobacter pylori -positive functional dyspepsia were treated with 100 mg of acotiamide three times a day for two weeks. Changes in 13 C-urea breath test were investigated before and after administration, and two weeks after administration as the follow-up period. The 13 C-urea breath test and the medical questionnaire of modified frequency scale for the symptoms of gastroesophageal reflux disease were conducted at every period. Nineteen patients were included for analysis. No patients showed negative in 13 C-urea breath test at Weeks 2 and 4. On the symptom scale, dyspepsia and total scores decreased from Week 0 to Week 2 and increased from Week 2 to Week 4, and the improvement rates of the dyspepsia score at Week 2 was 63%. In conclusion, we confirmed that acotiamide is unlikely to influence the result of 13 C-urea breath test and it may improve the symptoms of functional dyspepsia during Helicobacter pylori eradication treatment.
关键词：acotiamide;bacteriostatic effect;functional dyspepsia;Helicobacter pylori;urea breath test