文章基本信息

标题：Structure and Stereochemistry of Amphidinolide N Congeners from Marine Dinoflagellate Amphidinium Species
本地全文：下载
作者：Masashi Tsuda ; Mai Akakabe ; Mika Minamida 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2021
卷号：69
期号：1
页码：141-149
DOI：10.1248/cpb.c20-00745
出版社：The Pharmaceutical Society of Japan
摘要：Two highly potent cytotoxic 26-membered macrolides, isocaribenolide-I ( 1 ) and a chlorohydrin 2 , together with known amphidinolide N ( 3 ), have been isolated from a free-swimming dinoflagellate Amphidinium species (KCA09053 and KCA09056 strains) collected off Iriomote Island, Japan. The structures of 1 and 2 were determined to be a congener of 3 with an isobutyl terminus and the chlorohydrin form of 3 , respectively, by detailed analyses of spectroscopic data. The relative stereochemistries of 1 and 2 were elucidated by the conformational analyses based on NMR data.
关键词：macrolide;dinoflagellate;Amphidinium;cytotoxic activity