文章基本信息

标题：Isolation of Three New Diterpenes from Dodonaea viscosa
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作者：Toshinori Sagara ; Sachiko Sugimoto ; Yoshi Yamano 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2021
卷号：69
期号：1
页码：40-47
DOI：10.1248/cpb.c20-00327
出版社：The Pharmaceutical Society of Japan
摘要：An investigation into the methanol extracts obtained from the stems of Dodonaea viscosa led to the isolation of one nor-clerodane diterpene (1) and two labdane diterpenes (2, 3), as well as 17 known compounds ( 4 – 20 ). The structures of these compounds were elucidated based on chemical and spectral evidence. The stereochemical structure of the nor-clerodane diterpene was confirmed via its circular dichroism spectrum and calculated electronic circular dichroism spectrum. Isolated compounds were evaluated for their inhibitory effects on collagenase and tyrosinase. Since 5,7,4′-trihydroxy-3′-(4-hydroxy-3-methylbutyl)-5′-(3-methylbut-2-enyl)-3,6-dimethoxyflavone (9) showed collagenase inhibitory activity and scopoletin (12) had significant tyrosinase inhibitory activity, they were considered to be good candidates for cosmetic agents.
关键词：Dodonaea viscosa;Sapindaceae;diterpene;tyrosinase inhibitor;collagenase inhibitor;circular dichroism