文章基本信息

标题：Potential of an Interorgan Network Mediated by Toxic Advanced Glycation End-Products in a Rat Model
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作者：Shinya Inoue ; Takanobu Takata ; Yusuke Nakazawa 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2021
卷号：13
期号：1
页码：80
DOI：10.3390/nu13010080
出版社：MDPI Publishing
摘要：Excessive intake of glucose and fructose in beverages and foods containing high-fructose corn syrup (HFCS) plays a significant role in the progression of lifestyle-related diseases (LSRD). Glyceraldehyde-derived advanced glycation end-products (AGEs), which have been designated as toxic AGEs (TAGE), are involved in LSRD progression. Understanding of the mechanisms underlying the effects of TAGE on gene expression in the kidneys remains limited. In this study, DNA microarray analysis and quantitative real-time polymerase chain reaction (PCR) were used to investigate whether HFCS-consuming Wister rats generated increased intracellular serum TAGE levels, as well as the potential role of TAGE in liver and kidney dysfunction. HFCS consumption resulted in significant accumulation of TAGE in the serum and liver of rats, and induced changes in gene expression in the kidneys without TAGE accumulation or upregulation of receptor for AGEs (RAGE) upregulation. Changes in specific gene expression profiles in the kidney were more correlated with TAGE levels in the liver tissue than in the serum. These findings suggest a direct or indirect interaction may be present between the liver and kidneys that does not involve serum TAGE or RAGE. The involvement of internal signal transduction factors such as exosomes or cytokines without IL-1β and TNF-α is suggested to contribute to the observed changes in kidney gene expression.
关键词：toxic advanced glycation end-products (TAGE); high-fructose corn syrup (HFCS); serum levels of TAGE; intracellular TAGE; lifestyle-related diseases (LSRD); kidney; microarray toxic advanced glycation end-products (TAGE) ; high-fructose corn syrup (HFCS) ; serum levels of TAGE ; intracellular TAGE ; lifestyle-related diseases (LSRD) ; kidney ; microarray