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标题：Source and Composition in Amino Acid of Dietary Proteins in the Primary Prevention and Treatment of CKD
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作者：Pierre Letourneau ; Stanislas Bataille ; Philippe Chauveau 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：12
页码：1-21
DOI：10.3390/nu12123892
出版社：MDPI Publishing
摘要：Nutrition is a cornerstone in the management of chronic kidney disease (CKD). To limit urea generation and accumulation, a global reduction in protein intake is routinely proposed. However, recent evidence has accumulated on the benefits of plant-based diets and plant-derived proteins without a clear understanding of underlying mechanisms. Particularly the roles of some amino acids (AAs) appear to be either deleterious or beneficial on the progression of CKD and its complications. This review outlines recent data on the role of a low protein intake, the plant nature of proteins, and some specific AAs actions on kidney function and metabolic disorders. We will focus on renal hemodynamics, intestinal microbiota, and the production of uremic toxins. Overall, these mechanistic effects are still poorly understood but deserve special attention to understand why low-protein diets provide clinical benefits and to find potential new therapeutic targets in CKD.
关键词：chronic kidney disease; amino-acids; plant-based diet; low-protein diet chronic kidney disease ; amino-acids ; plant-based diet ; low-protein diet