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标题：Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution
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作者：Pauline Hautekiet ; Tim S. Nawrot ; Bram G. Janssen 等
期刊名称：Environment International
印刷版ISSN：0160-4120
电子版ISSN：1873-6750
出版年度：2021
卷号：147
页码：106332
DOI：10.1016/j.envint.2020.106332
出版社：Pergamon
摘要：Background Pro-inflammatory conditions such as air pollution might induce biological ageing. However, the available evidence on such an impact in children is still very scarce. We studied in primary schoolchildren the association of ambient residential air pollution exposure with telomere length (TL) and mitochondrial DNA content (mtDNAc), two important targets of the core axis of ageing. Methods Between 2012 and 2014, buccal TL and mtDNAc were repeatedly assessed using qPCR in 197 Belgian primary schoolchildren (mean age 10.3 years) as part of the COGNAC study. At the child’s residence, recent (week), sub-chronic (month) and chronic (year) exposure to nitrogen dioxide (NO 2 ), particulate matter ≤ 2.5 µm (PM 2.5 ) and black carbon (BC) were estimated using a high resolution spatiotemporal model. A mixed-effects model with school and subject as random effect was used while adjusting for a priori chosen covariates. Results An interquartile range (IQR) increment (1.9 µg/m 3 ) in chronic PM 2.5 exposure was associated with a 8.9% (95% CI: −15.4 to −1.9%) shorter TL. In contrast to PM 2.5 , chronic exposure to BC and NO 2 was not associated with TL but recent exposure to BC and NO 2 showed significant inverse associations with TL: an IQR increment in recent exposure to BC (0.9 µg/m 3 ) and NO 2 (10.2 µg/m 3 ) was associated with a 6.2% (95% CI: −10.6 to −1.6%) and 6.4% (95% CI: −11.8 to −0.7%) shorter TL, respectively. Finally, an IQR increment in chronic PM 2.5 exposure was associated with a 12.7% (95% CI: −21.7 to −2.6%) lower mtDNAc. However, no significant associations were seen for NO 2 and BC or for other exposure windows. Conclusion Chronic exposure to PM 2.5 below the EU threshold was associated with child’s shorter buccal TL and lower mtDNAc, while traffic-related pollutants (BC and NO 2 ) showed recent effects on telomere biology. Our data add to the literature on air pollution-induced effects of TL and mtDNAc, two measures part of the core axis of cellular ageing, from early life onwards.
关键词：Air pollution ; Biological ageing ; Biomarkers ; Children