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标题：Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults
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作者：Qin Li ; Yuan-Yuan Wang ; Yuming Guo 等
期刊名称：Environment International
印刷版ISSN：0160-4120
电子版ISSN：1873-6750
出版年度：2021
卷号：147
页码：106348
DOI：10.1016/j.envint.2020.106348
出版社：Pergamon
摘要：Background Limited studies have examined the impact of airborne particulate matter of 2.5 μm or less (PM 2.5 ) on renal function. No study has examined the effect of PM 1 , which is small enough to reach the blood circulation. We examined whether exposure to PM 1 or PM 2.5 affected renal function of young Han Chinese. Method We included 2,546,047 young adults who were aged 18 to 45 years, being Han ethnicity and had no chronic disease from a Chinese national birth cohort. Serum creatinine (Scr) of each participant was measured during the baseline examination. Estimated glomerular filtration rate (eGFR) were calculated for each participant using the latest Chronic Kidney Disease Epidemiology Collaboration equation. One-year average exposure to PM 1 and PM 2.5 prior to the health examination for each participant were estimated using machine learning models with satellite remote sensing information. Generalized additive mixed models were used to estimate associations between PM 1 or PM 2.5 and renal function after adjusting for detailed individual variables. Results A 10 μg/m 3 increment in PM 1 exposure was associated with −0.95% (95%CI: −1.04%, −0.87%) difference of eGFR in females and −0.37% (95%CI: −0.44%, −0.31%) in males. For PM 2.5 , the corresponding difference of eGFR was −0.99% (95%CI: −1.05%, −0.93%) in females and −0.48% (95%CI: −0.53%, −0.43%) in males, respectively. Associations between eGFR and PM were higher in females compared to males ( p < 0.05 for interaction test). Association with PM 1 were weaker than that with other fractions included in PM 2.5 . Participants who worked as farmers, were of normal weight, were not exposed to tobacco smoking, did not drink alcohol, had higher associations between eGFR and PM than their counterparts ( p < 0.05 for interaction test). Conclusion Exposure to PM 1 and PM 2.5 was associated with reduced renal function among Han Chinese at reproductive age.
关键词：PM1 ; PM2.5 ; Serum creatinine ; eGFR ; Young adults