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标题：SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?
其他标题：SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?
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作者：Stephen J. Winters
期刊名称：Clinical Diabetes and Endocrinology
印刷版ISSN：2055-8260
出版年度：2020
卷号：6
期号：1
页码：1-6
DOI：10.1186/s40842-020-00106-3
出版社：BioMed Central
摘要：Adult onset male hypogonadism (AOH) is a common clinical condition whose diagnosis and management are controversial, and is often characterized by a low level of SHBG, but our understanding of why testosterone levels are low when SHBG is low is incomplete. This retrospective chart review was performed to compare the relationship between SHBG and testosterone in the plasma of men presenting for evaluation of AOH with a cohort of men treated chronically with transdermal testosterone. The level of SHBG was < 30 nmol/L in 73% of men who presented for evaluation of AOH, and was inversely proportional to BMI in both the untreated and the testosterone-treated men. As in previous populations, the level of SHBG was highly positively correlated (r = 0.71, p < 0.01) with the total testosterone level in untreated men presenting for evaluation of AOH, but no relationship was found between the level of SHBG and total testosterone among men who were being treated with a transdermal testosterone preparation. These findings further support the idea that SHBG regulates testicular negative feedback either directly or by modulating the entry of testosterone or estradiol into cells in the hypothalamus and/or pituitary to control gonadotropin synthesis and secretion which explains in part the low testosterone levels in men with AOH. Not applicable
关键词：SHBG ; Testosterone ; Male hypogonadism ; Metabolic syndrome