文章基本信息

标题：Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a biological response modifier Glucan
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作者：Nobunao Ikewaki ; Kosagi-Sharaf Rao ; Armando Durant Archibold 等
期刊名称：Thrombosis Journal
印刷版ISSN：1477-9560
电子版ISSN：1477-9560
出版年度：2020
卷号：18
期号：1
页码：1-8
DOI：10.1186/s12959-020-00239-6
出版社：BioMed Central
摘要：Direct endothelial injury by viruses and dysregulation of clotting mechanisms due to cytokine storm are the major precipitating factors of mortality in COVID-19; both are attributed to a fundamental dysregulation of the immune system. While immune dysregulation can be attributed to several factors, the risk of associated thrombogenic disruption varies across individuals. This variation depends on several factors, such as comorbidities, including diabetes, hypertension, and cardiovascular diseases. When considering ethnic variations, the vulnerability of Caucasians, African Americans and Hispanics needs to be addressed before arriving at strategies to handle thromboembolic complications, which have been identified in recent reports as the leading causes of mortality in COVID-19. Although evaluation of D-dimer and prothrombin during admission is considered to predict prognosis and mortality, there are no preventive or prophylactic strategies before hospital admission. Herein, we present our perspectives on the effect of regular supplementation with the biological response modifier beta glucan based on its relevance to immune modulation. This effect is of paramount importance in decreasing the development of severe COVID-19 and reducing mortality against the background of coagulopathy, especially in vulnerable populations.