文章基本信息

标题：Seeing the forest for the trees: Retrieving plant secondary biochemical pathways from metabolome networks
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作者：Sandrien Desmet ; Marlies Brouckaert ; Wout Boerjan 等
期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2021
卷号：19
页码：72-85
DOI：10.1016/j.csbj.2020.11.050
出版社：Computational and Structural Biotechnology Journal
摘要：Over the last decade, a giant leap forward has been made in resolving the main bottleneck in metabolomics, i.e., the structural characterization of the many unknowns. This has led to the next challenge in this research field: retrieving biochemical pathway information from the various types of networks that can be constructed from metabolome data. Searching putative biochemical pathways, referred to as biotransformation paths, is complicated because several flaws occur during the construction of metabolome networks. Multiple network analysis tools have been developed to deal with these flaws, while in silico retrosynthesis is appearing as an alternative approach. In this review, the different types of metabolome networks, their flaws, and the various tools to trace these biotransformation paths are discussed.