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标题：Efecto del extracto acuoso de Chrysobalanus icaco sobre la adiposidad de ratas Wistar alimentadas con una dieta alta en grasas
其他标题：Efecto del extracto acuoso de Chrysobalanus icaco sobre la adiposidad de ratas Wistar alimentadas con una dieta alta en grasas
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作者：Portela-de-Sá, Heloisa Helena Pessoa ; Freitas, Paula Alexandre de ; Oliveira, Keciany Alves de 等
期刊名称：Nutrición Hospitalaria
印刷版ISSN：0212-1611
出版年度：2020
卷号：37
期号：4
页码：763-769
DOI：10.20960/nh.03030
出版社：Aula Médica Ediciones
摘要：Objective: the purpose of this study was to investigate the effects of Chrysobalanus icaco on adiposity and its mechanism of action in the gene and protein expression of acetyl-CoA carboxylase (ACC), a key enzyme in lipogenesis. Method: Wistar rats were divided into a regular or control group (CG) and a high-fat diet (HFD) group. HFD was treated with saline or aqueous extract of Chrysobalanus icaco (AECI) for four weeks. Body weight and food intake were assessed. Subcutaneous, retroperitoneal and periepididymal adipose tissue samples were collected and weighed. Adipocytes from periepididymal tissue were isolated and analyzed. The gene and protein expression of ACC in subcutaneous tissue was determined. Results: AECI showed no effect on intake or body weight. However, the weight of the fat pads and the gene and protein expression of ACC were lower, and glucose tolerance was improved. Conclusion: the aqueous extract of Chrysobalanus icaco proved beneficial for the treatment of obesity, preventing fat storage and improving glycemic homeostasis.
关键词：Chrysobalanus icaco;Obesidad;Acetil-CoA-carboxilasa
其他关键词：Chrysobalanus icaco;Obesity;Acetyl-CoA Carboxylase