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标题：Modulation of Food Intake by Differential TAS2R Stimulation in Rat
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作者：Carme Grau-Bové ; Alba Miguéns-Gómez ; Carlos González-Quilen 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2020
卷号：12
期号：12
页码：3784-3796
DOI：10.3390/nu12123784
出版社：MDPI Publishing
摘要：Metabolic surgery modulates the enterohormone profile, which leads, among other effects, to changes in food intake. Bitter taste receptors (TAS2Rs) have been identified in the gastrointestinal tract and specific stimulation of these has been linked to the control of ghrelin secretion. We hypothesize that optimal stimulation of TAS2Rs could help to modulate enteroendocrine secretions and thus regulate food intake. To determine this, we have assayed the response to specific agonists for hTAS2R5, hTAS2R14 and hTAS2R39 on enteroendocrine secretions from intestinal segments and food intake in rats. We found that hTAS2R5 agonists stimulate glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK), and reduce food intake. hTAS2R14 agonists induce GLP1, while hTASR39 agonists tend to increase peptide YY (PYY) but fail to reduce food intake. The effect of simultaneously activating several receptors is heterogeneous depending on the relative affinity of the agonists for each receptor. Although detailed mechanisms are not clear, bitter compounds can stimulate differentially enteroendocrine secretions that modulate food intake in rats.
关键词：TAS2R5; TAS2R39; TAS2R14; agonist; food intake; GLP1; CCK; PYY TAS2R5 ; TAS2R39 ; TAS2R14 ; agonist ; food intake ; GLP1 ; CCK ; PYY